GLOBAL PROTEIN CONJUGATION BY UBIQUITIN-LIKE-MODIFIERS DURING ISCHEMIC STRESS IS REGULATED BY MICRORNAS AND CONFERS ROBUST TOLERANCE TO ISCHEMIA.

Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia.

Hibernation torpor provides an excellent model of natural tolerance to ischemia.We have previously shown that massive global SUMOylation occurs during hibernation torpor in ground squirrels.We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to ox

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PRMT5 function and targeting in cancer

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response.Here we discuss the function of PRMT5, a member of the nine-member PRMT Detergents family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling

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Progress in the application of PGT in hereditary tumors

USB Adaptor Kit Hereditary tumors are essentially diseases caused by genetic material defects, and most of them exhibit Mendelian autosomal dominant inheritance.It not only endangers the health of patients, but also poses a serious threat to future generations.Preimplantation genetic testing (PGT) combined with in vitro fertilization and embryo tra

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A Comprehensive Survey on Spectrum Sensing in Cognitive Radio Networks: Recent Advances, New Challenges, and Future Research Directions

Cognitive radio technology has the potential to address the shortage of available radio spectrum 2-Layer Acrylic Ornament by enabling dynamic spectrum access.Since its introduction, researchers have been working on enabling this innovative technology in managing the radio spectrum.As a result, this research field has been progressing at a rapid pac

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